News
23andMe Cleared to Report 41 More BRCA Mutations
Posted OnAugust 31, 2023 byThe U.S. Food and Drug Administration (FDA) has approved 23andMe, which makes at-home genetic tests, to report the presence of 41 more variants, or mutations, of the BRCA1 and BRCA2 genes that are linked to a higher risk of developing breast, ovarian, prostate, and pancreatic cancers.Read More…
FDA approves niraparib and abiraterone acetate plus prednisone for BRCA-mutated metastatic castration-resistant prostate cancer
Posted OnAugust 29, 2023 byOn August 11, 2023, the Food and Drug Administration approved the fixed dose combination of niraparib and abiraterone acetate (Akeega, Janssen Biotech, Inc.), with prednisone, for adult patients with deleterious or suspected deleterious BRCA-mutated castration-resistant prostate cancer (mCRPC), as determined by an FDA-approved test.Read More…
FDA approves talazoparib with enzalutamide for HRR gene-mutated metastatic castration-resistant prostate cancer
Posted OnAugust 29, 2023 byOn June 20, 2023, the Food and Drug Administration approved talazoparib (Talzenna, Pfizer, Inc.) with enzalutamide for homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC).Read More…
2023 Grant Recipients
Posted OnJune 30, 2023 byCureBRCA Funds BRCA Prostate Cancer Research – Funded research includes grants to U.S. and international academic institutions: projects include research, screening, treatment, and outreach efforts for men with BRCA genetic mutations.Read More…
Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer
Posted OnApril 27, 2023 byHelicobacter pylori infection is a well-known risk factor for gastric cancer. However, the contribution of germline pathogenic variants in cancer-predisposing genes and their effect, when combined with H. pylori infection, on the risk of gastric cancer has not been widely evaluated.Read More…
Impact of concurrent tumour events on the prostate cancer outcomes of germline BRCA2 mutation carriers
Posted OnMarch 29, 2023 bySeveral studies have reported the association of germline BRCA2 (gBRCA2) mutations with poor clinical outcomes in prostate cancer (PCa), but the impact of concurrent somatic events on gBRCA2 carriers survival and disease progression is unknown.Read More…
Request for Applications
Posted OnJanuary 3, 2023 byCureBRCA will consider funding BRCA-related initiatives that involve prevention, detection, screening, and/or treatment for men at risk for BRCA-related cancers. Applications are due by March 1, 2023. The online application is available.Read More…
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling
Posted OnOctober 31, 2022 byNewly diagnosed breast or ovarian cancer patients who carry common cancer-associated mutations have similar or better short-term survival rates than those with no mutations, researchers report.
New BRCA-targeting drug could offer hope in treating advanced prostate cancer
Posted OnOctober 14, 2022 byNewly diagnosed breast or ovarian cancer patients who carry common cancer-associated mutations have similar or better short-term survival rates than those with no mutations, researchers report.
