Impact of concurrent tumour events on the prostate cancer outcomes of germline BRCA2 mutation carriers
Posted OnMarch 29, 2023 bySeveral studies have reported the association of germline BRCA2 (gBRCA2) mutations with poor clinical outcomes in prostate cancer (PCa), but the impact of concurrent somatic events on gBRCA2 carriers survival and disease progression is unknown.Read More…
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling
Posted OnOctober 31, 2022 byNewly diagnosed breast or ovarian cancer patients who carry common cancer-associated mutations have similar or better short-term survival rates than those with no mutations, researchers report.
New BRCA-targeting drug could offer hope in treating advanced prostate cancer
Posted OnOctober 14, 2022 byNewly diagnosed breast or ovarian cancer patients who carry common cancer-associated mutations have similar or better short-term survival rates than those with no mutations, researchers report.
Breast, Ovarian Cancer Study Finds Ties Between Types of BRCA Alterations, Treatment Response
Posted OnJuly 7, 2022 byEpigenetic changes to the promoter regions of BRCA1 appear to have a different effect on treatment response than genomic alterations in BRCA1 or BRCA2 in triple-negative breast cancer (TNBC) or ovarian carcinoma patients, new research suggests.Read More…
Health News – Why men should be tested for BRCA gene
Posted OnJune 28, 2022 byIt’s a genetic mutation that could put you at risk for certain cancers. While most people associate BRCA with breast cancer, the gene can carry risks for both men and women.
PARP Inhibitors – Effective in Men with BRCA-Mutant Prostate Cancer
Posted OnFebruary 14, 2022 byMen with prostate cancer have genomic defects that can be targeted with PARP Inhibitors. All men should undergo genomic testing.
Faulty BRCA genes linked to prostate and pancreatic cancers
Posted OnJanuary 25, 2022 byA study published today in the Journal of Clinical Oncology has provided the strongest evidence to date of these links and helped researchers estimate more accurately the associated risk.Read More…
Women with genetic mutations fare no worse with breast or ovarian cancer, study finds
Posted OnOctober 1, 2021 byNewly diagnosed breast or ovarian cancer patients who carry common cancer-associated mutations have similar or better short-term survival rates than those with no mutations, researchers report.
This Breast Cancer Gene Is Less Well Known, but Nearly as Dangerous
Posted OnAugust 17, 2021 byPALB2 is not as well known as BRCA, but mutations of the gene can raise a woman’s risk for breast cancer almost as much.
